[Barrett esophagus with severe dysplasia in argon beam therapy]. / Barrett-Osophagus mit schweren Dysplasien unter Argon-Beamer-Therapie.
Z Gastroenterol
; 36(4): 301-6, 1998 Apr.
Article
en De
| MEDLINE
| ID: mdl-9612928
ABSTRACT
A curative therapy of Barrett's esophagus is not established, yet. However, in prospective clinical research trials, a combined therapy of potent pharmacological acid suppression with superficial coagulation of metaplastic epithelium is examined. By local coagulation using photodynamic therapy, laser or argon plasma coagulation, a complete reconstitution of squamous epithelium should be achieved. We report on a case of a patient with Barrett's esophagus and low-grade dysplasia, who developed high-grade dysplastic cell formations under argon plasma coagulation therapy. As part of a clinical study, the patient was treated over a period of one year monthly. We monitored the result of the therapy over the period of one year with endoscopy, histolgical investigations and DNA image cytometry. Ultimately a decision in favour of a further surgical management was made. The diagnostic instruments to identify patients with a high risk for the development of adenocarcinoma are discussed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fotoquimioterapia
/
Lesiones Precancerosas
/
Esófago de Barrett
/
Neoplasias Esofágicas
/
Adenocarcinoma
/
Coagulación con Láser
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Male
/
Middle aged
Idioma:
De
Revista:
Z Gastroenterol
Año:
1998
Tipo del documento:
Article