Mucosal and systemic antibody levels against Helicobacter pylori do not parallel gastric inflammatory changes.
Ital J Gastroenterol Hepatol
; 30(1): 36-9, 1998 Feb.
Article
en En
| MEDLINE
| ID: mdl-9615262
ABSTRACT
BACKGROUND AND AIMS:
Mucosal and systemic antibodies against Helicobacter pylori have been detected but their role in the natural history of Helicobacter pylori-related diseases is unclear. In this study, the levels of Helicobacter pylori IgG and IgA were related to the grade of gastritis. PATIENTS ANDMETHODS:
A series of 152 dyspeptic patients underwent gastroscopy with biopsies. Helicobacter pylori was detected in 131 (86%) patients. Samples of serum and unstimulated saliva were collected. Helicobacter pylori IgG and IgA were measured in homogenised gastric biopsies, saliva and serum by an in-house enzyme linked immunosorbent assay.RESULTS:
Levels of gastric mucosa, salivary and serum Helicobacter pylori IgG were higher (p < or = 0.01) in Helicobacter pylori positive than negative patients. Likewise, levels of gastric mucosa and serum Helicobacter pylori IgA were higher (p < 0.01) in Helicobacter pylori positive patients. Gastric mucosa, saliva and serum Helicobacter pylori antibody levels did not differ between superficial and atrophic, active and inactive Helicobacter pylori positive gastritis.CONCLUSIONS:
These data indicate that gastric inflammatory changes may not necessarily be related to the antibody response against Helicobacter pylori.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Helicobacter pylori
/
Infecciones por Helicobacter
/
Mucosa Gástrica
/
Gastritis
/
Anticuerpos Antibacterianos
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Ital J Gastroenterol Hepatol
Asunto de la revista:
GASTROENTEROLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Italia