Diorganotin(IV) complexes of pyridoxal thiosemicarbazone: synthesis, spectroscopic properties and biological activity.
J Inorg Biochem
; 69(4): 283-92, 1998 Mar.
Article
en En
| MEDLINE
| ID: mdl-9654752
ABSTRACT
The complexes [SnR2(L)] (R = Me, Et, Bu, Ph; H2L = pyridoxal thiosemicarbazone) have been prepared and characterized. In the light of the spectral properties of the complexes in the solid state (IR, mass, Mössbauer) the bideprotonated thiosemicarbazonato anion is O(phenolic)-, N(3)-, S-bonded to the tin atom which probably has trigonal bipyramidal coordination with N(3) atom and R groups occupying equatorial positions. NMR ( 1H, 13C and 119Sn) data in CDCl3 or DMSO-d6 suggest that this coordinative picture remains in these solutions. The ethyl, butyl and phenyl derivatives suppress proliferation of Friend erithroleukaemia cells (FLC). Of the pyridoxal thiosemicarbazone complexes so far evaluated. [SnBu2(L)] and [SnPh2(L)] showed the lowest thresholds for inhibition of FLC proliferation. The effects of these compounds on DMSO-induced differentiation of FLC, DNA synthesis and reverse transcriptase were also assayed.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Compuestos Orgánicos de Estaño
/
Piridoxal
/
Tiosemicarbazonas
/
Antineoplásicos
Límite:
Animals
Idioma:
En
Revista:
J Inorg Biochem
Año:
1998
Tipo del documento:
Article
País de afiliación:
España