Binding of murine leukemia virus Gag polyproteins to KIF4, a microtubule-based motor protein.
J Virol
; 72(8): 6898-901, 1998 Aug.
Article
en En
| MEDLINE
| ID: mdl-9658142
ABSTRACT
A cDNA clone encoding a cellular protein that interacts with murine leukemia virus (MuLV) Gag proteins was isolated from a T-cell lymphoma library. The sequence of the clone is identical to the C terminus of a cellular protein, KIF4, a microtubule-associated motor protein that belongs to the kinesin superfamily. KIF4-MuLV Gag associations have been detected in vitro and in vivo in mammalian cells. We suggest that KIF4 could be involved in Gag polyprotein translocation from the cytoplasm to the cell membrane.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Proteínas Virales
/
Productos del Gen gag
/
Cinesinas
/
Virus de la Leucemia Murina
/
Proteínas Asociadas a Microtúbulos
/
Proteínas del Tejido Nervioso
Límite:
Animals
Idioma:
En
Revista:
J Virol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos