Immunohistochemical analysis of the oncoprotein c-erbB-2 expression in oral benign and malignant lesions.
Int J Oral Maxillofac Surg
; 27(3): 209-12, 1998 Jun.
Article
en En
| MEDLINE
| ID: mdl-9662015
Thirty-seven samples of oral mucosa were analysed and divided histologically into groups of normal mucosa (6), hyperplastic lesions (6), dysplastic lesions (14), and squamous cell carcinoma (11). All lesions displayed some expression of c-erbB-2 but the distribution and intensity of expression varied strongly according to the differentiation. The lower the epithelial differentiation of the sample, the higher the expression of c-erbB-2 oncoprotein showing very strong staining in carcinoma samples. This suggests that in oral carcinoma, transformation might be related to c-erbB-2 interaction.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Leucoplasia Bucal
/
Neoplasias de la Boca
/
Carcinoma de Células Escamosas
/
Regulación Neoplásica de la Expresión Génica
/
Receptor ErbB-2
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Int J Oral Maxillofac Surg
Asunto de la revista:
ODONTOLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Finlandia
Pais de publicación:
Dinamarca