Cerebral N-acetylaspartate is low in patients with multiple sclerosis and abnormal visual evoked potentials.
AJNR Am J Neuroradiol
; 19(6): 1047-54, 1998.
Article
en En
| MEDLINE
| ID: mdl-9672010
ABSTRACT
PURPOSE:
Our purpose was to compare cerebral proton MR metabolite changes in patients with multiple sclerosis (MS) and abnormal visual evoked potentials (VEPs) with those in MS patients with normal VEPs.METHODS:
Seventeen subjects with clinically definite MS were studied with VEPs and MR spectroscopic imaging. Proton MR metabolites were measured using a fast spectroscopic imaging technique called proton echo-planar spectroscopic imaging (PEPSI). Kurtzke's Expanded Disability Status Scale (EDSS) score was also ascertained for each subject to obtain a clinical rating. Twelve regions of interest within the visual pathway of the cerebrum were evaluated for levels of N-acetylaspartate (NAA), choline, creatine, and the presence or absence of MR-detectable lesions.RESULTS:
PEPSI NAA values (water-normalized, CSF-corrected) were significantly lower in MS subjects with abnormal VEPs than in subjects with normal VEPs. MR-detectable lesion fractions and EDSS scores were also significantly different between the two VEP groups, but NAA comparison had a P value 100 times less than either of these measures.CONCLUSION:
In patients with MS, NAA measurements in the optic pathways of the brain were sensitive to VEP abnormalities. NAA was more sensitive to VEP changes than were choline, creatine, MR-detectable lesions, and EDSS score.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Imagen por Resonancia Magnética
/
Espectroscopía de Resonancia Magnética
/
Neuromielitis Óptica
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Ácido Aspártico
/
Potenciales Evocados Visuales
/
Esclerosis Múltiple
Límite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
AJNR Am J Neuroradiol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos