Anti-T-cell receptor therapy in murine experimental systemic lupus erythematosus.
Immunol Lett
; 62(1): 1-8, 1998 May.
Article
en En
| MEDLINE
| ID: mdl-9672140
ABSTRACT
Experimental systemic lupus erythematosus (SLE), similar to that observed after immunization with the human anti-DNA mAb 16/6 Id+, could be induced in mice by injection of 16/6 Id specific T-cell lines. The above T-cell lines were exclusively CD4+ CD8- and the majority of cells expressed the Vbeta8 T-cell receptor (TCR) gene products. Furthermore, lymph node cells of mice immunized with the 16/6 Id were enriched with CD4+ Vbeta8+ T-cells. The TCR used by 16/6 Id-specific T-cells showed a limited homology in their CDR3 junctional regions. Nevertheless, mice injected with the anti-Vbeta8 mAb developed autoantibody titers that were not significantly different from those found in the non-treated, 16/6 Id-injected group.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunización Pasiva
/
Receptores de Antígenos de Linfocitos T alfa-beta
/
Lupus Eritematoso Sistémico
Límite:
Animals
/
Female
/
Humans
Idioma:
En
Revista:
Immunol Lett
Año:
1998
Tipo del documento:
Article
País de afiliación:
Israel