[Neuronal regeneration and the glial barrier]. / Respousse axonale et obstacle glial.
Rev Neurol (Paris)
; 153(8-9): 515-20, 1997 Sep.
Article
en Fr
| MEDLINE
| ID: mdl-9684001
ABSTRACT
The dogma of abortive axonal regrowth set by Cajal (1914) is now broken since the demonstration by Aguayo (1982) that severed axons can regrow in an appropriate environment. Over the last decade, the impediments to such a regrowth in the central nervous system of higher vertebrates have been identified, or, at least, some of them. On the one hand, the inhibitory molecules synthesized and secreted by oligodendrocytes have been counteracted by appropriate antibodies (Schnell & Schwab, 1990), which have permitted some regrowth of severed cortico-spinal axons in the rat spinal cord. On the other hand, the reduction by a pharmacological treatment of hypertrophy and hyperplasia of astrocytes has permitted some regrowth of monoaminergic axons in an hemisected cord (Gimenez y Ribotta et al. 1995). Finally, the identification of a subcategory of astrocytes, the tanycytes of the basal hypothalamus, as a permissive substrate for axonal regeneration opens a new avenue for future research.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Axones
/
Neuroglía
/
Regeneración Nerviosa
Límite:
Animals
/
Humans
Idioma:
Fr
Revista:
Rev Neurol (Paris)
Año:
1997
Tipo del documento:
Article