Immunonutrition: the role of arginine.
Nutrition
; 14(7-8): 611-7, 1998.
Article
en En
| MEDLINE
| ID: mdl-9684265
ABSTRACT
Clearly, arginine has great potential as an immunomodulator and may prove useful in catabolic conditions such as severe sepsis and postoperative stress. there is a body of evidence suggesting that supplemental arginine upregulates immune function and reduces the incidence of postoperative infection. More modest improvements in nitrogen balance have been observed. Tumor response to arginine appears to depend on the immunogenicity of the particular tumor and on the requirement of arginine by the tumor as a growth substrate. Of note, ornithine shares the thymotrophic, immunostimulatory and secretagogue effects of arginine. It is, therefore, likely that these compounds share the same cellular mechanism of action or that arginine acts via increasing the concentration of available ornithine. The role of arginine in the injured patient and in the tumor-bearing host demands additional study based on the promising experimental evidence regarding the supplemental use of arginine.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Arginina
/
Inmunidad
/
Fenómenos Fisiológicos de la Nutrición
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Nutrition
Asunto de la revista:
CIENCIAS DA NUTRICAO
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos