Ontogeny of neuropeptide Y expression in response to deprivation in lean Zucker rat pups.
Am J Physiol
; 275(2): R466-70, 1998 08.
Article
en En
| MEDLINE
| ID: mdl-9688681
ABSTRACT
Hypothalamic neuropeptide Y (NPY) activity is believed to play an important role in the response to food deprivation in adult rats. Little is known, however, about the role of the hypothalamic NPY system in the control of food intake in the preweanling rat. To address this issue, we examined the effect of deprivation on arcuate nucleus preproNPY expression in lean Zucker rat pups, using in situ hybridization. PreproNPY expression within the arcuate nucleus was localized to cells in the medial portion. Twenty-four hours of food, water, and maternal deprivation significantly increased the relative abundance of preproNPY mRNA in pups on postnatal day (P) 2, P9, P12, and P15 by 14-31%. This response, however, was not observed on P5. The absence of an effect on P5 and the magnitude of the response at the other ages tested were not correlated with the amount of weight lost during deprivation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Privación de Agua
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Neuropéptido Y
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Envejecimiento
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Regulación del Desarrollo de la Expresión Génica
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Privación de Alimentos
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Hipotálamo
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Privación Materna
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Neuronas
Límite:
Animals
Idioma:
En
Revista:
Am J Physiol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos