Heparin-coated bypass circuits: effects on inflammatory response in pediatric cardiac operations.
Ann Thorac Surg
; 66(1): 166-71, 1998 Jul.
Article
en En
| MEDLINE
| ID: mdl-9692458
ABSTRACT
BACKGROUND:
This study was designed to investigate whether clinical signs of the inflammatory response in pediatric cardiac patients are reduced by heparin-coated cardiopulmonary bypass circuits and how this could be explained by differences in the pathophysiologic mechanisms involved.METHODS:
In a randomized, prospective study 19 patients underwent cardiopulmonary bypass either with Carmeda BioActive Surface bypass circuits (n = 9) or with identical noncoated circuits (control, n = 10). Clinical parameters were recorded during the first 48 hours after the start of operation. Blood samples for determination of terminal complement complex, soluble form of E-selectin, and beta-thromboglobulin were obtained perioperatively up to 24 hours after operation.RESULTS:
All clinical and inflammatory mediators showed a tendency in favor of the group with heparin-coated circuits. When analyzed on a point-by-point basis there were significant differences in postoperative central body temperature, soluble E-selectin levels, and beta-thromboglobulin levels (all p < 0.05).CONCLUSIONS:
These data suggest that the use of heparin-coated cardiopulmonary bypass offers clinical benefit and tends to reduce the release of inflammatory mediators.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Heparina
/
Puente Cardiopulmonar
/
Síndrome de Respuesta Inflamatoria Sistémica
/
Cardiopatías Congénitas
/
Anticoagulantes
Tipo de estudio:
Clinical_trials
/
Etiology_studies
/
Observational_studies
/
Prognostic_studies
Límite:
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Ann Thorac Surg
Año:
1998
Tipo del documento:
Article
País de afiliación:
Países Bajos