Association between transfusion of stored blood and infective bacterial complications after resection for colorectal cancer.
Eur J Surg
; 164(6): 449-56, 1998 Jun.
Article
en En
| MEDLINE
| ID: mdl-9696446
ABSTRACT
OBJECTIVE:
To examine the association between blood transfusion and bacterial infective complications after resection for colorectal adenocarcinoma.DESIGN:
Retrospective cohort study.SETTING:
District hospital; Norway.SUBJECTS:
446 consecutive patients having resection of colorectal adenocarcinoma. MAIN OUTCOMEMEASURES:
Postoperative bacterial infective morbidity in hospital.RESULTS:
112 patients (25%) developed postoperative infections in hospital. Univariate analysis showed that the development of infection was significantly associated with increasing age (p=0.02), rectal compared with colonic cancer (p=0.002), preoperative radiotherapy (p=0.005), blood loss during operation (p=0.001), the extent of the primary tumour (T stage) T4 compared with T1-T3 (p=0.004), the presence of regional lymph node metastasis (N stage) N1-N3 compared with N0 (p=0.01), operating surgeon 1 (p=0.009), operating surgeon 2 (p=0.03), and blood transfusion (p < 0.001). Multivariate logistic regression analysis showed that the following variables were independent predictors of infection age, rectal compared with colonic cancer, T stage, N stage, and blood transfusion. The corrected odds ratios for infection were 1.5 (95% CI 0.8 to 2.8) when 1-3 units of blood were given and 3.1 (95% CI 1.6 to 6.0) when more than three units were given. Storage time did not affect the rate of postoperative infections in patients given transfusions.CONCLUSION:
Transfusion of non-filtered stored allogeneic blood suspended in saline-adenine-glucose-mannitol is an independent risk factor for the development of postoperative infections in hospital in patients having a resection of colorectal cancer.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Infecciones Bacterianas
/
Conservación de la Sangre
/
Neoplasias Colorrectales
/
Adenocarcinoma
/
Reacción a la Transfusión
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Eur J Surg
Año:
1998
Tipo del documento:
Article
País de afiliación:
Noruega