Continuous intrathecal baclofen infusions induced a marked increase of the transcranially evoked silent period in a patient with generalized dystonia.
Muscle Nerve
; 21(9): 1209-12, 1998 Sep.
Article
en En
| MEDLINE
| ID: mdl-9703450
ABSTRACT
We observed a marked prolongation of the transcranially evoked silent period during continuous intrathecal administration of high doses of the gamma-aminobutyric acid (GABA)B receptor agonist baclofen in a patient with generalized dystonia. Size of motor evoked potentials and central conduction time remained unchanged during intrathecal baclofen administration. The selective prolongation of the silent period during high-dose continuous intrathecal baclofen therapy supports the notion that GABA(B)-ergic intracortical interneurons play a part in the generation of the transcranially evoked silent period.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Baclofeno
/
Potenciales Evocados Motores
/
Distonía
/
Electromiografía
/
Corteza Motora
Límite:
Adult
/
Humans
Idioma:
En
Revista:
Muscle Nerve
Año:
1998
Tipo del documento:
Article
País de afiliación:
Alemania