Combined effect of dorzolamide and latanoprost on the rate of aqueous humor flow.
Am J Ophthalmol
; 126(2): 191-6, 1998 Aug.
Article
en En
| MEDLINE
| ID: mdl-9727512
ABSTRACT
PURPOSE:
To determine whether latanoprost, an ocular hypotensive agent believed to enhance uveoscleral outflow of aqueous humor, augments the aqueous-suppressing effect of dorzolamide, a topical carbonic anhydrase inhibitor.METHODS:
Twenty-four normal subjects underwent measurement of aqueous humor flow by fluorophotometry to determine the flow with placebo, with dorzolamide, and with a combination of dorzolamide and latanoprost.RESULTS:
The flow of aqueous humor was suppressed 13% by dorzolamide but not by latanoprost. Latanoprost did not augment the effect of dorzolamide on aqueous humor flow; latanoprost and dorzolamide had additive ocular hypotensive effects.CONCLUSIONS:
The uveoscleral flow effect of latanoprost does not improve the aqueous-suppressing effect of dorzolamide, but the two drugs have additive ocular hypotensive effects.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Humor Acuoso
/
Prostaglandinas F Sintéticas
/
Sulfonamidas
/
Tiofenos
/
Inhibidores de Anhidrasa Carbónica
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Ophthalmol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos