Ropinirole for the treatment of early Parkinson disease: a 12-month experience. Ropinirole Study Group.
Arch Neurol
; 55(9): 1211-6, 1998 Sep.
Article
en En
| MEDLINE
| ID: mdl-9740115
ABSTRACT
OBJECTIVE:
To evaluate ropinirole hydrochloride as dopaminergic monotherapy in patients with early Parkinson disease.DESIGN:
A 6-month extension of a double-blind, placebo-controlled study.SETTING:
Ambulatory care at 22 different sites in the United States. PATIENTS Patients who successfully completed the initial 6-month study could enter the 6-month extension study (ropinirole, n = 70; placebo, n = 77). INTERVENTION Use of ropinirole or placebo therapy. MAIN OUTCOMEMEASURES:
The efficacy variables were the number of patients who successfully completed the 12-month study and did not require supplemental levodopa, the number of patients requiring supplemental levodopa, and the proportion of patients having an insufficient therapeutic response.RESULTS:
Significantly fewer ropinirole-treated patients met criteria for insufficient therapeutic response (23 [19.8%] of 116) or required the initiation of levodopa therapy (22 [19%] of 116) compared with placebo-treated patients (60 [48%] of 125 patients for insufficient therapeutic response; 57 [45.6%] of 125 patients for additional levodopa). Significantly more ropinirole-treated patients (51 [44.0%] of 116) successfully completed the 12-month study and did not require supplemental levodopa compared with placebo-treated patients (28 [22.4%] of 125). The incidence of adverse experiences and patient withdrawals was low.CONCLUSION:
Ropinirole was effective and well tolerated as monotherapy for 12 months in patients with early Parkinson disease.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedad de Parkinson
/
Indoles
/
Antiparkinsonianos
Tipo de estudio:
Clinical_trials
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Arch Neurol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos