Orthopaedic manifestations of chronic graft-versus-host disease.
J Pediatr Orthop
; 18(5): 572-5, 1998.
Article
en En
| MEDLINE
| ID: mdl-9746402
ABSTRACT
Chronic graft-versus-host disease (GVHD) is a well-recognized complication of allogeneic bone marrow transplantation (BMT). Musculoskeletal manifestations include joint contractures, polymyositis, polyserositis, and fasciitis. We present 14 patients with orthopaedic complications of chronic GVHD. Long-term conservative management of joint contractures with physical therapy and orthotics was generally successful in restoring patients' premorbid functional status. Surgical release of joint contractures yielded poor results and rendered the affected joints unresponsive to further conservative treatment. Surgical intervention in the treatment of joint contractures resulting from chronic GVHD does not appear qualitatively to improve functional status in patients affected with this disease process.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Contractura
/
Enfermedad Injerto contra Huésped
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Child
/
Female
/
Humans
/
Infant
/
Male
Idioma:
En
Revista:
J Pediatr Orthop
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos