Synergistic antinociceptive interaction between sevoflurane and intrathecal fentanyl in dogs.
Br J Anaesth
; 80(6): 800-6, 1998 Jun.
Article
en En
| MEDLINE
| ID: mdl-9771311
ABSTRACT
This study determined the nature of the antinociceptive interaction between sevoflurane and intrathecal fentanyl on somatosympathetic reflexes in anaesthetized dogs. Afferent A delta- and C-fibre-mediated somatosympathetic reflexes, evoked by supramaximal electrical stimulation of tibial nerves, were recorded from renal sympathetic nerves. The effect of fentanyl alone, administered intrathecally (i.t.) in incremental doses from 2 to 64 micrograms, was compared with the effect of the same doses during the administration of 1.5% sevoflurane. The mean ED50s for the depressant effect of fentanyl (i.t.) on A delta and C reflexes were 35.6 micrograms and 14.2 micrograms while 1.5% sevoflurane, when administered alone, depressed them by 15.5% (P < 0.05) and 27.5% (P < 0.01) respectively. During the administration of 1.5% sevoflurane, the mean ED50s of fentanyl (i.t.) for the depression of A delta and C reflexes were reduced by 76% and 75%, to 8.5 micrograms and 3.5 micrograms respectively. The combined antinociceptive effects of sevoflurane and intrathecal fentanyl were not additive but exhibited a high degree of synergistic interaction.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nociceptores
/
Fentanilo
/
Anestésicos por Inhalación
/
Analgésicos Opioides
/
Éteres Metílicos
Límite:
Animals
Idioma:
En
Revista:
Br J Anaesth
Año:
1998
Tipo del documento:
Article