[Intestinal permeability in the first year of life. The effect of diarrhea]. / Permeabilidad intestinal en el primer año de vida. Efecto de la diarrea.
An Esp Pediatr
; 49(2): 125-8, 1998 Aug.
Article
en Es
| MEDLINE
| ID: mdl-9773545
ABSTRACT
OBJECTIVE:
The permeability of the intestinal mucosa to lactulose and mannitol was explored longitudinally in infants at 1, 3-4 and 11-12 months of age. This was also evaluated during the episodes of diarrhea that they suffered during follow-up. PATIENTS ANDMETHODS:
Sugar excretion was measured by gas chromatography in five-hour urine samples.RESULTS:
A decrease in lactulose excretion was observed, which became significant at 11-12 months of age (p = 0.02). No changes were detected in mannitol excretion, although this showed a tendency to decrease. The lactulose/mannitol (L/M) ratio remained unchanged. During the 15 episodes of diarrhea observed in these infants during the 12 month follow-up, a considerable increase in this ratio was seen, due mainly to increased lactulose excretion.CONCLUSIONS:
It is hypothesized that the decrease in lactulose excretion between one and 11-12 months of age is part of the maturational process of the intestinal barrier, while diarrhea results in increased permeability due to damage to the absorptive epithelium.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Diarrea
/
Absorción Intestinal
/
Mucosa Intestinal
Tipo de estudio:
Observational_studies
/
Prognostic_studies
Límite:
Humans
/
Infant
Idioma:
Es
Revista:
An Esp Pediatr
Año:
1998
Tipo del documento:
Article
País de afiliación:
Chile