Synthesis and biological evaluation of a series of substituted pyrazolo[3,4-d]-1,2,3-triazoles and pyrazolo[3,4-d]oxazoles.
Arch Pharm (Weinheim)
; 331(9): 269-72, 1998 Sep.
Article
en En
| MEDLINE
| ID: mdl-9793481
ABSTRACT
In view of the biological relevance of triazole-based heterocyclic structures as antifungal, antiviral, and antitumor agents, we have synthesized a series of substituted pyrazolo[3,4-d]-1,2,3-triazoles (2e-h, 2j, 4b) which we evaluated for their cytostatic and antiviral (HIV-1 included) activity and for their capability to inhibit the multiplication of various human pathogenic fungi and bacteria. Moreover, the biological activities of a few compounds, namely pyrazolo[3,4-d]oxazoles (3a-e) and pyrazolo[3,4-d]-1,2,3-triazoles (2a-d, 4a, 5), previously obtained by us but not investigated for their biological activity, were also studied. Only compounds 3a-e were endowed with a significative antiproliferative activity on the human lymphoblastoid cell line MT-4 cells. All pyrazole derivatives proved ineffective in protecting cell cultures against the HIV-1-induced cytopathogenicity, and none of the compounds was active against the bacteria and fungi tested.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oxazoles
/
Triazoles
/
Antibacterianos
Límite:
Humans
Idioma:
En
Revista:
Arch Pharm (Weinheim)
Año:
1998
Tipo del documento:
Article
País de afiliación:
Italia