Differential signaling and hierarchical response thresholds induced by an immunodominant peptide of myelin basic protein and an altered peptide ligand in human T cells.
Hum Immunol
; 59(11): 679-89, 1998 Nov.
Article
en En
| MEDLINE
| ID: mdl-9796736
ABSTRACT
Changes in peptide antigen concentration or structure can have a profound effect on T cell responsiveness by inducing selected T cell effector functions. In this study, we have compared the biological responses of an MBP83-99-specific human Th0 T cell clone (TCC) stimulated with increasing concentrations of native peptide or an altered peptide ligand (APL). Our results show that the hierarchy of response thresholds for proliferation and cytokine secretion is similar for native peptide and APL. However, because a much higher concentration of the APL is required to evoke the same degree of response, the cytokine profile is shifted towards a Th2-like response relative to the same concentration of native peptide. In addition, we observed qualitative differences in TCR signal transduction triggered by native peptide and a weak agonist APL even at concentrations that elicit similar biological responses. Thus, the relationship between TCR signaling and biological responses may be more complex than previously recognized.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Receptores de Antígenos de Linfocitos T
/
Transducción de Señal
/
Citocinas
/
Linfocitos T Colaboradores-Inductores
/
Proteínas Adaptadoras Transductoras de Señales
/
Proteína Básica de Mielina
/
Proteínas de la Membrana
Tipo de estudio:
Qualitative_research
Límite:
Humans
Idioma:
En
Revista:
Hum Immunol
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos