[Receptors of monoamine in sympathetic preganglionic neurons of neonatal rat spinal cord in vitro].
Sheng Li Xue Bao
; 49(5): 581-4, 1997 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-9813500
ABSTRACT
By means of intracellular recordings from spinal cord slices of neonatal rats in vitro, the effects of 5-hydroxytryptamine (5-HT), nor-adrenaline (NA) and adrenaline (AD) on membrane potential in sympathetic preganglionic neurons (SPN) were observed, in order to clarify whether these neuron contain a single type of the monoamine receptor or in combination with more than one type of receptors. The results showed that (1) 5-HT, NA and AD induced membrane depolarization respectively in 57.1% (16/28), 60% (15/25) and 52.4% (11/21) of SPN. (2) According to the reactions of SPN to the three monoamines, several subtypes of SPN could be divided those sensitive to all the three monoamines (3/19), those sensitive to two of them (9/19), those only sensitive to one type of monoamines (4/19) and those insensitive at all (3/19). The significance of coexistence of more than one type of the three monoamines in a single neuron remains to be elucidated.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Fibras Autónomas Preganglionares
/
Médula Espinal
/
Receptores Adrenérgicos
/
Receptores de Serotonina
Límite:
Animals
Idioma:
Zh
Revista:
Sheng Li Xue Bao
Año:
1997
Tipo del documento:
Article