KCNQ2 and KCNQ3 potassium channel subunits: molecular correlates of the M-channel.
Science
; 282(5395): 1890-3, 1998 Dec 04.
Article
en En
| MEDLINE
| ID: mdl-9836639
ABSTRACT
The M-current regulates the subthreshold electrical excitability of many neurons, determining their firing properties and responsiveness to synaptic input. To date, however, the genes that encode subunits of this important channel have not been identified. The biophysical properties, sensitivity to pharmacological blockade, and expression pattern of the KCNQ2 and KCNQ3 potassium channels were determined. It is concluded that both these subunits contribute to the native M-current.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Potasio
/
Canales de Potasio
Límite:
Adult
/
Animals
/
Humans
Idioma:
En
Revista:
Science
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos