Partial volume decrease of the thalamus in relatives of patients with schizophrenia.
Am J Psychiatry
; 155(12): 1784-6, 1998 Dec.
Article
en En
| MEDLINE
| ID: mdl-9842796
ABSTRACT
OBJECTIVE:
The authors' goal was to compare the thalamic, total brain, and intracranial volumes of patients with schizophrenia, their healthy siblings, and normal comparison subjects.METHOD:
Magnetic resonance imaging (MRI) brain scans were obtained for 32 same-sex siblings who were discordant for schizophrenia and 32 matched normal comparison subjects.RESULTS:
Mean total thalamic volume, corrected for total brain volume, was significantly different among affected siblings, unaffected siblings, and comparison subjects. Thalamic volume was smallest in the patients; thalamic volume in their siblings was smaller than that of comparison subjects but larger than that of the patients with schizophrenia.CONCLUSIONS:
These results suggest that healthy siblings of patients with schizophrenia partially share the thalamic abnormalities of their affected relatives.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Esquizofrenia
/
Tálamo
/
Familia
Límite:
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Psychiatry
Año:
1998
Tipo del documento:
Article
País de afiliación:
Países Bajos