Assessment of cardiac rejection by MR-imaging and MR-spectroscopy.
Eur J Cardiothorac Surg
; 14(4): 426-30, 1998 Oct.
Article
en En
| MEDLINE
| ID: mdl-9845150
ABSTRACT
BACKGROUND:
Detection of cardiac rejection is a major problem in cardiac transplantation. The gold standard is, and remains, endomyocardial biopsy.PURPOSE:
Evaluation of MR-imaging and MR-spectroscopy for detection of cardiac rejection.METHODS:
Orthotopic cardiac transplantation (HTX) was performed in 13 pigs (body weight 30 kg). All animals obtained immunosuppressive (triple) therapy for 1 week after the operation. Thereafter immunosuppression was stopped to induce cardiac rejection. MRI and MRS (1.5 Tesla General Electrics Signa) were performed pre- and post-operatively on days 10, 17, 24 and 31. The degree of rejection was determined post-operatively using endomyocardial biopsy (Texas grading score).RESULTS:
(1) MR-imaging LV function remained unchanged after HTX. LV mass increased (+42%; P < 0.05) with cardiac rejection. (2) MR-spectroscopy a marked reduction in the ratio of phosphocreatine and adenosine triphosphate, respectively, to inorganic phosphate was observed in the rejecting hearts. (3) Histologic grading confirmed cardiac rejection after stopping immunosuppression. The Texas score was 5.7+/-0.8 at autopsy.CONCLUSIONS:
MR-imaging and MR-spectroscopy allow the detection of changes associated with cardiac rejection. Both techniques are correlated with histologic rejection. However, endomyocardial biopsy remains the gold standard for reliable detection of cardiac rejection.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Imagen por Resonancia Magnética
/
Espectroscopía de Resonancia Magnética
/
Trasplante de Corazón
/
Rechazo de Injerto
Límite:
Animals
Idioma:
En
Revista:
Eur J Cardiothorac Surg
Asunto de la revista:
CARDIOLOGIA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Suiza