[Studies on transdermal delivery system of dihydroetorphine hydrochloride].
Yao Xue Xue Bao
; 31(10): 770-4, 1996.
Article
en Zh
| MEDLINE
| ID: mdl-9863246
ABSTRACT
A transdermal delivery system of dihydroetorphine hydrochloride (DHE-TDS) was developed. The DHE-TDS mainly composed of polyvinyl alcohol, polyvinyl pyrrolidone and lactose. Tests on rabbits showed only slight skin irritation according to federal hazardous substances act. By giving DHE-TDS to rabbits, DHE release was shown to be governed by first-order mechanism. When DHE-TDS was given to Wistar rats, a relatively stable blood drug concentration was observed from 4-32 h after drug administration. Writhing tests showed that one dose of DHE-TDS would maintain the narcotic action on rats for at least 48 h.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Etorfina
/
Analgésicos Opioides
Límite:
Animals
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Año:
1996
Tipo del documento:
Article