SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor.
Cell
; 95(6): 779-91, 1998 Dec 11.
Article
en En
| MEDLINE
| ID: mdl-9865696
ABSTRACT
Smads transmit signals from transmembrane ser/thr kinase receptors to the nucleus. We now identify SARA (for Smad anchor for receptor activation), a FYVE domain protein that interacts directly with Smad2 and Smad3. SARA functions to recruit Smad2 to the TGFbeta receptor by controlling the subcellular localization of Smad2 and by interacting with the TGFbeta receptor complex. Phosphorylation of Smad2 induces dissociation from SARA with concomitant formation of Smad2/Smad4 complexes and nuclear translocation. Furthermore, mutations in SARA that cause mislocalization of Smad2 inhibit TGFbeta-dependent transcriptional responses, indicating that the regulation of Smad localization is important for TGFbeta signaling. These results thus define SARA as a component of the TGFbeta pathway that brings the Smad substrate to the receptor.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Serina Endopeptidasas
/
Proteínas Portadoras
/
Transactivadores
/
Factor de Crecimiento Transformador beta
/
Dedos de Zinc
/
Receptores de Factores de Crecimiento Transformadores beta
/
Proteínas de Xenopus
/
Péptidos y Proteínas de Señalización Intracelular
/
Proteínas de Unión al ADN
Tipo de estudio:
Prognostic_studies
Límite:
Adult
/
Animals
/
Humans
Idioma:
En
Revista:
Cell
Año:
1998
Tipo del documento:
Article
País de afiliación:
Canadá
Pais de publicación:
EEUU
/
ESTADOS UNIDOS
/
ESTADOS UNIDOS DA AMERICA
/
EUA
/
UNITED STATES
/
UNITED STATES OF AMERICA
/
US
/
USA