Synthetic arabinofuranosyl oligosaccharides as mycobacterial arabinosyltransferase substrates.
Bioorg Med Chem Lett
; 8(5): 437-42, 1998 Mar 03.
Article
en En
| MEDLINE
| ID: mdl-9871594
ABSTRACT
A series of arabinofuranosyl oligosaccharides found as constituent parts of the polysaccharide portion of the cell wall of Mycobacterium tuberculosis have been chemically synthesized. Screening of these oligosaccharides as substrates for arabinosyltransferases present in mycobacterial membrane preparations suggests that modified oligosaccharide analogs as small as disaccharides may be inhibitors of glycan biosynthesis. Such inhibitors would be of potential utility as lead compounds in the identification of new drugs for the treatment of mycobacterial infections.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oligosacáridos
/
Pentosiltransferasa
/
Mycobacterium smegmatis
/
Mycobacterium tuberculosis
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos