Synthesis of novel fluorinated coumarins: excellent UV-light excitable fluorescent dyes.
Bioorg Med Chem Lett
; 8(22): 3107-10, 1998 Nov 17.
Article
en En
| MEDLINE
| ID: mdl-9873685
ABSTRACT
Two new fluorinated fluorescent dyes, 6,8-difluoro-7-hydroxy-4-methylcoumarin (Marina Blue) and 3-carboxy-6,8-difluoro-7-hydroxycoumarin (Pacific Blue), exhibit excellent photophysical properties among a series of novel fluorinated 7-hydroxycoumarins. Most of these fluorinated coumarins have quantum yields (0.63 to 0.89) equal to or higher than that of the parent compound (0.63), which, in combination with their lower pKaS and higher photostability, make them superior fluorescent dyes for use as reporter molecules in biological systems.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cumarinas
/
Colorantes Fluorescentes
Idioma:
En
Revista:
Bioorg Med Chem Lett
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos