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Reconstitution of a voltage and calcium dependent potassium channel from rat cerebellum.
Ottolia, M; Babini, E; Gazzotti, P; Possani, L D; Prestipino, G.
Afiliación
  • Ottolia M; Istituto di Cibernetica e Biofisica, CNR, Genova, Italy.
Brain Res ; 815(2): 410-3, 1999 Jan 09.
Article en En | MEDLINE | ID: mdl-9878856
Membrane vesicles from rat cerebellum were reconstituted into lipid bilayers. The activity of two different potassium channels was recorded: (1) a small conducting voltage dependent potassium channel insensitive to [Ca2+]i, (2) a calcium and voltage dependent potassium channel (KCa). KCa channels had a conductance of (302+/-15) pS (n=5) and were activated by [Ca2+]i and membrane depolarizations. They were blocked by tetraethylamonium (TEA) and charybdotoxin (CTX) but insensitive to noxiustoxin (NTX). Finally, we showed the blocking effect of Androctonus australis Hector (AaH) scorpion venom on KCa channels from rat cerebellum.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canales de Potasio / Activación del Canal Iónico / Cerebelo / Calcio Límite: Animals Idioma: En Revista: Brain Res Año: 1999 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos
Buscar en Google
Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canales de Potasio / Activación del Canal Iónico / Cerebelo / Calcio Límite: Animals Idioma: En Revista: Brain Res Año: 1999 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Países Bajos