CD1d-restricted immunoglobulin G formation to GPI-anchored antigens mediated by NKT cells.
Science
; 283(5399): 225-9, 1999 Jan 08.
Article
en En
| MEDLINE
| ID: mdl-9880256
ABSTRACT
Immunoglobulin G (IgG) responses require major histocompatibility complex (MHC)-restricted recognition of peptide fragments by conventional CD4(+) helper T cells. Immunoglobulin G responses to glycosylphosphatidylinositol (GPI)- anchored protein antigens, however, were found to be regulated in part through CD1d-restricted recognition of the GPI moiety by thymus-dependent, interleukin-4-producing CD4(+), natural killer cell antigen 1.1 [(NK1.1)+] helper T cells. The CD1-NKT cell pathway regulated immunogobulin G responses to the GPI-anchored surface antigens of Plasmodium and Trypanosoma and may be a general mechanism for rapid, MHC-unrestricted antibody responses to diverse pathogens.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Inmunoglobulina G
/
Subgrupos de Linfocitos T
/
Glicosilfosfatidilinositoles
/
Linfocitos T Colaboradores-Inductores
/
Antígenos CD1
/
Antígenos de Protozoos
Límite:
Animals
Idioma:
En
Revista:
Science
Año:
1999
Tipo del documento:
Article
País de afiliación:
Australia