ATP released from astrocytes mediates glial calcium waves.
J Neurosci
; 19(2): 520-8, 1999 Jan 15.
Article
en En
| MEDLINE
| ID: mdl-9880572
ABSTRACT
Calcium waves represent a widespread form of intercellular communication. Although they have been thought for a long time to require gap junctions, we recently demonstrated that mouse cortical astrocytes use an extracellular messenger for calcium wave propagation. The present experiments identify ATP as a major extracellular messenger in this system. Medium collected from astrocyte cultures during (but not before) calcium wave stimulation contains ATP. The excitatory effects of medium samples and of ATP are blocked by purinergic receptor antagonists and by pretreatment with apyrase; these same purinergic receptor antagonists block propagation of electrically evoked calcium waves. ATP, applied at the concentration measured in medium samples, evokes responses that are qualitatively and quantitatively similar to those evoked by those medium samples. These data implicate ATP as an important transmitter between CNS astrocytes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Adenosina Trifosfato
/
Astrocitos
/
Señalización del Calcio
Límite:
Animals
Idioma:
En
Revista:
J Neurosci
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos