Evaluation of a new ultrashort triple therapy for Helicobacter pylori disease.
Aliment Pharmacol Ther
; 12(12): 1269-72, 1998 Dec.
Article
en En
| MEDLINE
| ID: mdl-9882037
ABSTRACT
BACKGROUND:
1-week proton pump inhibitor-based triple therapies are considered the most effective and convenient drug combinations for curing Helicobacter pylori infection. Short therapies, lasting less than 1 week have been investigated rarely.AIM:
To assess the efficacy and tolerability of a 3-day lansoprazole triple therapy after 1 day of lansoprazole pre-treatment.METHODS:
Seventy H. pylori-positive (rapid urease test and histology) patients received LAzT3 regimen (lanzoprazole 30 mg b.d. and azithromycin 500 mg o.m. for 3 days; tinidazole 2000 mg o.m. on day 1 and 1000 mg o.m. on days 2-3) after 1 day of lansoprazole pretreatment. Patients with active ulcer received lansoprazole 30 mg o.m. for an additional 4 weeks. Follow-up gastroscopy was carried out 4-6 weeks after completion of therapy. Eradication was defined as negative histology and rapid urease test.RESULTS:
Four patients failed to attend the follow-up endoscopy. One patient complained of minor side-effects. H. pylori was eradicated in 57 of 66 patients suitable for evaluation, with a per-protocol cure rate of 86.3% (95%CI 76-94%), and an intention-to-treat cure rate of 81.4% (95%CI 70-90%).CONCLUSIONS:
This new ultrashort triple therapy including lansoprazole, azithromycin and tinidazole seems to be effective in eradicating H. pylori. It is safe and well-tolerated, and may be taken into consideration as a valid alternative to the better known and widely used 1-week proton pump inhibitor-based triple therapies.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Omeprazol
/
Helicobacter pylori
/
Infecciones por Helicobacter
/
Antiulcerosos
Tipo de estudio:
Guideline
/
Observational_studies
Límite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Aliment Pharmacol Ther
Asunto de la revista:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Año:
1998
Tipo del documento:
Article
País de afiliación:
Italia