A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer.
Cancer Res
; 59(1): 35-43, 1999 Jan 01.
Article
en En
| MEDLINE
| ID: mdl-9892180
ABSTRACT
A novel putative tumor suppressor gene and member of the NF2/ERM/ 4.1 superfamily was isolated using Differential Display PCR (DDPCR) on primary lung tumors. When reintroduced into nonexpressing non-small cell lung carcinoma cell lines, this gene, named DAL-1 (for Differentially expressed in Adenocarcinoma of the Lung), was shown to suppress growth. In addition, significantly reduced expression (>50%) of DAL-1 was measured in 39 primary non-small cell lung carcinoma tumors as compared with patient-matched normal lung tissue. Immunocytochemical staining with a polyclonal anti-DAL-1 antibody localized the protein to the plasma membrane, particularly at cell-cell contact points, a pattern reminiscent of other members of the protein 4.1 superfamily including ezrin and NF2. The data suggest DAL-1 is a novel membrane-associated protein with potential to play an important role in the origin and progression of lung cancer.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neuropéptidos
/
Regulación Neoplásica de la Expresión Génica
/
Genes Supresores de Tumor
/
Carcinoma de Pulmón de Células no Pequeñas
/
Proteínas del Citoesqueleto
/
Proteínas Supresoras de Tumor
/
Neoplasias Pulmonares
/
Proteínas de la Membrana
Límite:
Humans
Idioma:
En
Revista:
Cancer Res
Año:
1999
Tipo del documento:
Article
País de afiliación:
Estados Unidos