Nitric oxide inhibits HIV-1 replication in human astrocytoma cells.
Biochem Biophys Res Commun
; 254(1): 200-2, 1999 Jan 08.
Article
en En
| MEDLINE
| ID: mdl-9920758
ABSTRACT
Astroglial cells represent a target for HIV infection in the central nervous system. In astrocytes, HIV infection is poorly productive, being characterized by a persistent state of viral latency. However, activation of the nuclear factor NF-kappaB and its binding to HIV long terminal repeat (LTR) can induce HIV replication. Moreover, nitric oxide (NO) can affect NF-kappaB activation in glial cells. Therefore, we hypothesize that NO may reduce HIV replication in human astroglial cells by inhibiting HIV-1 LTR transcriptional activity. In this respect, we show that NO donors reduce viral replication in HIV-1-infected human astrocytoma T67 cells, taken as an astroglial model. Furthermore, using transfected T67 cells, we demonstrate that NO donors inhibit HIV-1 LTR transcriptional activity. These results suggest that the use of NO-releasing drugs may represent a potential, novel approach in inhibiting HIV replication in the central nervous system.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Astrocitoma
/
Replicación Viral
/
Neoplasias Encefálicas
/
Infecciones por VIH
/
VIH-1
/
Donantes de Óxido Nítrico
/
Óxido Nítrico
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
En
Revista:
Biochem Biophys Res Commun
Año:
1999
Tipo del documento:
Article
País de afiliación:
Italia