Ionic mechanism of GABAA biphasic synaptic potentials in gustatory nucleus of the solitary tract.
Ann N Y Acad Sci
; 855: 486-7, 1998 Nov 30.
Article
en En
| MEDLINE
| ID: mdl-9929643
ABSTRACT
Gamma-aminobutyric acid (GABA) is the principal neurotransmitter of synaptic inhibition in the gustatory nucleus of the solitary tract (rNST). High-frequency activation of GABA neurons in the rNST results in biphasic inhibitory postsynaptic potentials (IPSPs) that are initially hyperpolarizing but then became depolarizing. Our results indicate that high-frequency stimulation evokes redistribution of Cl- and K+ ions that shifts IPSP reversal potential in a more positive direction, which produces a biphasic or depolarizing IPSP.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Núcleo Solitario
/
Transmisión Sináptica
/
Ácido gamma-Aminobutírico
Límite:
Animals
Idioma:
En
Revista:
Ann N Y Acad Sci
Año:
1998
Tipo del documento:
Article
País de afiliación:
Estados Unidos