PSA, Gleason score and epidemiology of prostate cancer (PC) in Grenada
In. Caribbean Public Health Agency. Caribbean Public Health Agency: 60th Annual Scientific Meeting. Kingston, The University of the West Indies. Faculty of Medical Sciences, 2015. p.[1-75]. (West Indian Medical Journal Supplement).
Monography
en En
| MedCarib
| ID: med-17965
Biblioteca responsable:
TT2.1
ABSTRACT
OBJECTIVE:
To assess (1) the incidence and survival rates of PC, (2) the distribution of prostatic-specific antigen (PSA) and Gleason score in Grenada. DESIGN ANDMETHODS:
A PC hospital-based series from the only urologist in the island was assembled. Age-adjusted incidence rates, PSA levels and Gleason scores for Grenada were analyzed and compared with US-Blacks and incidence rates from International Agency for Research on Cancer (IARC)-contributing Caribbean registries.RESULTS:
601 new cases of PC diagnosed between 1997-2013 equate to an annual age-adjusted incidence rate of 69.3 per 100,000 in Grenada. This is similar to the Jamaica rate of 77.3, but much inferior to those of US-Blacks 197.7 and Martinique 177.8. The median PSA level in Grenada was 18.0 ng/ml compared to 7.0 among US-Blacks (P<0.05). 47% of Grenadians with PC were in the high risk PSA category (>20ng/ml), compared to only 17% US-Blacks. Lower tract urinary infection and positive digital rectal examination were both significantly associated with high risk PSA and high risk Gleason score (Gleason sum ≥ 8).CONCLUSION:
The lower PC incidence in Grenada and Jamaica is likely a reflection of lower prevalence of PSA-testing. Thus, PSA levels fall more substantially in the high risk category.
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Colección:
01-internacional
Base de datos:
MedCarib
Asunto principal:
Próstata
/
Neoplasias de la Próstata
/
Incidencia
/
Tasa de Supervivencia
/
Antígeno Prostático Específico
/
Grenada
Tipo de estudio:
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
/
Screening_studies
País/Región como asunto:
Caribe
/
Caribe ingles
/
Grenada
Idioma:
En
Revista:
West Indian Medical Journal Supplement
Año:
2015
Tipo del documento:
Monography
Pais de publicación:
Jamaica