Short report: long-term serum antibody isotype responses to Strongyloides stercoralis filariform antigens in eight patients treated with ivermectin
Am J Trop Med Hyg
; 55(5): 474-6, Nov. 1996.
Article
en En
| MedCarib
| ID: med-2385
Biblioteca responsable:
JM3.1
Ubicación: JM3.1; RC960.A42
ABSTRACT
The enzyme-linked immunosorbant assay was used to investigate long term changes in serum immunoglobulin G1 (IgG1), IgG4, IgE, and IgA against Strongyloides stercoralis phosphate-buffered saline-soluble filariform larval antigens in eight Jamaican patients treated with ivermectin. Patients were followed for periods of between 170 and 542 days. Based on repeated formalin-ether concentration and agar plate culture, all patients were found to be uninfected up to 18 months following chemotherapy. Generally, all antibody isotype levels decreased following treatment, although there was considerable heterogeneity among patients. In a single patient with hyperinfection, the decrease in IgG4 was marginal and may represent a treatment failure. Reduction in serum antibody isotype responses to S. stercoralis following treatment may be used to assess the effectiveness of ivermectin in treating endemic strongyloides (AU)
Buscar en Google
Colección:
01-internacional
Base de datos:
MedCarib
Asunto principal:
Estrongiloidiasis
/
Ivermectina
/
Anticuerpos Antihelmínticos
/
Strongyloides stercoralis
/
Antihelmínticos
Límite:
Humans
Idioma:
En
Revista:
Am J Trop Med Hyg
Año:
1996
Tipo del documento:
Article