Human T cell lymphotropic virus: necessity for and feasibility of a vaccine
Ciba Found Symp
; 187: 47-55, 1994.
Article
en En
| MedCarib
| ID: med-4730
Biblioteca responsable:
JM3.1
Ubicación: JM3.1; Reprint Collection
ABSTRACT
Human T cell lymphotropic virus types I and II (HTLV-I/II) are endemic in certain areas of the world. The cause two life-threatening diseases, adult T cell leukaemia/lymphoma and tropical spastic paraparesis. A vaccine is needed because in developing countries there are no other feasible preventive interventions against these diseases and in Western countries intravenous drug users at high risk for HTLV-I and HTLV-II infections and the health workers in contact with such populations must be protected. We have developed a rat model in which we observed variations of susceptibility to viral infection between inbred strains, the most susceptible being Fischer F344, and the possibility of viral latency in the nervous system. We have prepared a recombinant adenovirus vector that expresses the HTLV-I envelope glycoprotein env in HeLa cells. A target human population in French Guyana, in which the prevalence rate reaches 5.6 percent in one ethnic group (Bonis), has been identified for possible intervention (AU)
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Colección:
01-internacional
Base de datos:
MedCarib
Asunto principal:
Vacunas Virales
/
Vacunas Sintéticas
/
Virus Linfotrópico T Tipo 1 Humano
/
Infecciones por HTLV-I
/
Virus Linfotrópico T Tipo 2 Humano
/
Infecciones por HTLV-II
Tipo de estudio:
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Ciba Found Symp
Año:
1994
Tipo del documento:
Article