Chlamydia trachomatis antibody and DNA determination in ectopic pregnancy in Trinidad
West Indian med. j
; 49(Supp 2): 25, Apr. 2000.
Artículo
en Inglés
| MedCarib
| ID: med-982
Biblioteca responsable:
JM3.1
Ubicación: JM3.1; R18.W4
ABSTRACT
OBJECTIVE:
To determine the prevalence of C. trachomatis in ectopic pregnancy by serum IgG and IgM antibody and by chlamydia DNA in endometrial, Fallopian tube and ovarian tissues. DESIGN ANDMETHODS:
A cross-sectional study included 32 women presenting with tubal ectopic pregnancy and 94 fertile controls. Methods employed were ELISA for IgG and IgM and Polymerase Chain Reaction (PCR) and in situ hybridization (ISH) for DNA.RESULTS:
Chlamydial IgG and IgM antibody detection was higher in the ectopic than the control groups (IgG, p<0.01; IgM, p<0.01). A similar finding was also noted for chlamydia DNA by PCR (p<0.05). DNA detection was also significantly higher at each site in the upper genital tract (endometrium p<0.01, Fallopian tube p<0.05, ovary p<0.05).CONCLUSION:
By antibody detection, this study confirms the role played by genital tract C. trachoma infection and subsequently ectopic pregnancy, but more importantly, identifies chlamydial DNA in upper genital tract tissues. These results support allocation of resources towards screening programmes for C. trachomatis.(Au)
Buscar en Google
Colección:
Bases de datos internacionales
Base de datos:
MedCarib
Asunto principal:
Embarazo Ectópico
/
ADN
/
Chlamydia trachomatis
Tipo de estudio:
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
País/Región como asunto:
Caribe Inglés
/
Trinidad y Tobago
Idioma:
Inglés
Revista:
West Indian med. j
Año:
2000
Tipo del documento:
Artículo