Early-life obesity and adulthood colorectal cancer risk: a meta-analysis
Rev Panam Salud Publica
; 43, ene. 2019
Artículo
en Inglés
| PAHO-IRIS
| ID: phr-49674
Biblioteca responsable:
US1.1
ABSTRACT
[ABSTRACT]. Objective. This meta-analysis examines the relationship between early-life obesity and risk of colorectal cancer (CRC) in adulthood. Methods. A systematic search of Google Scholar, PubMed, and reference data was conducted. Fifteen relevant studies were identified and meta-analyzed, for men and women separately. A random-effects model was used to compare the multivariable-adjusted relative risks (RR) of overall and subsite-specific CRC to the highest versus lowest categories of body mass index (BMI) in early life. Meta-regression was performed on factors that may have contributed to between-study heterogeneity. Results. High early-life BMI was associated with a 39% increased risk of CRC in adult men (RR = 1.39, 95%CI = 1.20 – 1.62, P < 0.0001) and a 19% increased risk of CRC in adult women (RR = 1.19, 95%CI = 1.06 – 1.35, P = 0.004). No statistically significant heterogeneity was identified in meta-regression according to tumor subsite (RR = 1.06, 95%CI = 0.97 – 1.17, RR = 1.08, 95%CI = 0.99 – 1.18 for male and female proximal colon cancer; RR = 1.51, 95%CI = 1.22 – 1.87, RR = 1.08, 95%CI = 0.98 – 1.19 for male and female distal colon cancer; and RR = 1.39, 95%CI = 1.1 – 1.77, RR = 1.51, 95%CI = 0.94 – 2.03 for male and female rectal cancer) or other factors, including age of BMI assessment, self-reported or measured BMI, and adjustment for smoking. Conclusions. The results suggest that high early-life BMI is associated with increased risk of CRC in adulthood. Further studies should investigate adult CRC risk in early-life obese individuals from non-Western countries and the underlying mechanisms by which early-life adiposity may influence CRC pathogenesis.
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Base de datos:
PAHO-IRIS
Asunto principal:
Neoplasias del Recto
/
Neoplasias Colorrectales
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Índice de Masa Corporal
/
Metaanálisis
/
Obesidad
Tipo de estudio:
Ensayo clínico controlado
/
Estudio de etiología
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Estudio pronóstico
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Factores de riesgo
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Revisión sistemática
Idioma:
Inglés
Año:
2019
Tipo del documento:
Artículo