Seroprevalence of anti-SARS-CoV-2 IgG in asymptomatic and pauci-symptomatic people over a 5 month survey in Argentina
Rev Panam Salud Publica
; 45, jun. 2021
Artículo
en Inglés
| PAHO-IRIS
| ID: phr-54288
Biblioteca responsable:
US1.1
ABSTRACT
[ABSTRACT]. Objective. To evaluate the seroprevalence of COVID-19 infection in pauci-symptomatic and asymptomatic people, the associated epidemiological factors, and IgG antibody kinetic over a 5-month period to get a better knowledge of the disease transmissibility and the rate of susceptible persons that might be infected. Methods. Seroprevalence was evaluated by a cross-sectional study based on the general population of Santa Fe, Argentina (non-probabilistic sample) carried out between July and November 2020. A subgroup of 20 seropositive individuals was followed-up to analyze IgG persistence. For the IgG anti-SARS-CoV-2 antibodies detection, the COVID-AR IgG® ELISA kit was used. Results. 3 000 individuals were included conforming asymptomatic and pauci-symptomatic groups (n=1 500 each). From the total sample, only 8.83% (n=265) presented reactivity for IgG anti-SARS-CoV-2. A significant association was observed between positive anti-SARS-CoV-2 IgG and a history of contact with a confirmed case; the transmission rate within households was approximately 30%. In the pauci-symptomatic group, among the seropositive ones, anosmia and fever presented an OR of 16.8 (95% CI 9.5-29.8) and 2.7 (95% CI 1.6-4.6), respectively (p <0.001). In asymptomatic patients, IgG levels were lower compared to pauci-symptomatic patients, tending to decline after 4 months since the symptoms onset. Conclusion. We observed a low seroprevalence, suggestive of a large population susceptible to the infection. Anosmia and fever were independent significant predictors for seropositivity. Asymptomatic patients showed lower levels of antibodies during the 5-month follow-up. IgG antibodies tended to decrease over the end of this period regardless of symptoms.
Texto completo:
Disponible
Colección:
Bases de datos de organismos internacionales
Contexto en salud:
ODS3 - Meta 3.3 Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
Problema de salud:
Neumonía
Base de datos:
PAHO-IRIS
Asunto principal:
Argentina
/
Estudios Seroepidemiológicos
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Epidemiología
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Infecciones por Coronavirus
/
Coronavirus
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Enfermedades Asintomáticas
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Betacoronavirus
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Anosmia
/
COVID-19
Tipo de estudio:
Estudio diagnóstico
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Estudio observacional
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Estudio de prevalencia
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Estudio pronóstico
/
Factores de riesgo
País/Región como asunto:
America del Sur
/
Argentina
Idioma:
Inglés
Año:
2021
Tipo del documento:
Artículo