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Neutralization of spike 69/70 deletion, E484K, and N501Y SARS-CoV-2 by BNT162b2 vaccine-elicited sera
Xuping Xie; Yang Liu; Jianying Liu; Xianwen Zhang; Jing Zou; Camila R. Fontes-Garfias; Hongjie Xia; Kena A. Swanson; Mark Cutler; David Cooper; Vineet D Menachery; Scott Weaver; Philip Dormitzer; Pei-Yong Shi.
Afiliación
  • Xuping Xie; University of Texas Medical Branch
  • Yang Liu; University of Texas Medical Branch
  • Jianying Liu; University of Texas Medical Branch
  • Xianwen Zhang; University of Texas Medical Branch
  • Jing Zou; University of Texas Medical Branch
  • Camila R. Fontes-Garfias; University of Texas Medical Branch
  • Hongjie Xia; University of Texas Medical Branch
  • Kena A. Swanson; Pfizer
  • Mark Cutler; Pfizer
  • David Cooper; Pfizer
  • Vineet D Menachery; University of Texas Medical Branch
  • Scott Weaver; University of Texas Medical Branch
  • Philip Dormitzer; Pfizer
  • Pei-Yong Shi; University of Texas Medical Branch
Preprint en En | PREPRINT-BIORXIV | ID: ppbiorxiv-427998
Artículo de revista
Un artículo publicado en revista científica está disponible y probablemente es basado en este preprint, por medio del reconocimiento de similitud realizado por una máquina. La confirmación humana aún está pendiente.
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ABSTRACT
We engineered three SARS-CoV-2 viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants N501Y from UK and SA; 69/70-deletion+N501Y+D614G from UK; and E484K+N501Y+D614G from SA. Neutralization geometric mean titers (GMTs) of twenty BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
Licencia
cc_by_nc_nd
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Idioma: En Año: 2021 Tipo del documento: Preprint
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-BIORXIV Idioma: En Año: 2021 Tipo del documento: Preprint