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Enhanced fitness of SARS-CoV-2 variant of concern B.1.1.7, but not B.1.351, in animal models
Lorenz Ulrich; Nico Joel Halwe; Adriano Taddeo; Nadine Ebert; Jacob Schön; Christelle Devisme; Bettina Salome Trüeb; Bernd Hoffmann; Manon Wider; Meriem Bekliz; Manel Essaidi-Laziosi; Marie Luisa Schmidt; Daniela Niemeyer; Victor Max Corman; Anna Kraft; Aurélie Godel; Laura Laloli; Jenna Nicole Kelly; Angele Breithaupt; Claudia Wylezich; Inês Margarida Berenguer Veiga; Mitra Gultom; Kenneth Adea; Benjamin Meyer; Christiane Eberhardt; Lisa Thomann; Monika Gsell-Albert; Fabien Labroussaa; Jörg Jores; Artur Summerfield; Christian Drosten; Isabella Anne Eckerle; Ronald Dijkman; Donata Hoffmann; Volker Thiel; Martin Beer; Charaf Benarafa.
Afiliación
  • Lorenz Ulrich; Institute of Diagnostic Virology, Friedrich Loeffler Institut, Federal Research Institute of Animal Health, Greifswald Insel Riems, Germany
  • Nico Joel Halwe; Institute of Diagnostic Virology, Friedrich Loeffler Institut, Federal Research Institute of Animal Health, Greifswald Insel Riems, Germany
  • Adriano Taddeo; Institute of Virology and Immunology, Mittelhaeusern, Switzerland
  • Nadine Ebert; Institute of Virology and Immunology, Bern, Switzerland
  • Jacob Schön; Institute of Diagnostic Virology, Friedrich Loeffler Institut, Federal Research Institute of Animal Health, Greifswald Insel Riems, Germany
  • Christelle Devisme; Institute of Virology and Immunology, Mittelhaeusern, Switzerland
  • Bettina Salome Trüeb; Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
  • Bernd Hoffmann; Institute of Diagnostic Virology, Friedrich Loeffler Institut, Federal Research Institute of Animal Health, Greifswald Insel Riems, Germany
  • Manon Wider; Institute for Infectious Diseases, University of Bern, Bern, Switzerland
  • Meriem Bekliz; Department of Microbiology and Molecular Medicine, University of Geneva, Switzerland
  • Manel Essaidi-Laziosi; Department of Microbiology and Molecular Medicine, University of Geneva, Switzerland
  • Marie Luisa Schmidt; Charite, Universitaetsmedizin Berlin, Institute of Virology, Berlin, Germany
  • Daniela Niemeyer; Charite, Universitaetsmedizin Berlin, Institute of Virology, Berlin, Germany
  • Victor Max Corman; Charite, Universitaetsmedizin Berlin, Institute of Virology, Berlin, Germany
  • Anna Kraft; Institute of Diagnostic Virology, Friedrich Loeffler Institut, Federal Research Institute of Animal Health, Greifswald Insel Riems, Germany
  • Aurélie Godel; Institute of Virology and Immunology, Mittelhaeusern, Switzerland
  • Laura Laloli; Institute for Infectious Diseases, University of Bern, Bern, Switzerland
  • Jenna Nicole Kelly; Institute of Virology and Immunology, Bern, Switzerland
  • Angele Breithaupt; Department of Experimental Animal Facilities and Biorisk Management, Friedrich Loeffler Institut; Greifswald Insel Riems, Germany
  • Claudia Wylezich; Institute of Diagnostic Virology, Friedrich Loeffler Institut, Federal Research Institute of Animal Health, Greifswald Insel Riems, Germany
  • Inês Margarida Berenguer Veiga; Institute of Virology and Immunology, Bern, Switzerland
  • Mitra Gultom; Institute for Infectious Diseases, University of Bern, Bern, Switzerland
  • Kenneth Adea; Department of Microbiology and Molecular Medicine, University of Geneva, Switzerland
  • Benjamin Meyer; Centre for Vaccinology, Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
  • Christiane Eberhardt; Centre for Vaccinology, Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland
  • Lisa Thomann; Institute of Virology and Immunology, Bern, Switzerland
  • Monika Gsell-Albert; Institute for Infectious Diseases, University of Bern; Bern, Switzerland
  • Fabien Labroussaa; Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern; Bern, Switzerland
  • Jörg Jores; Institute of Veterinary Bacteriology, Vetsuisse Faculty, University of Bern, Bern, Switzerland
  • Artur Summerfield; Institute of Virology and Immunology, Mittelhaeusern, Switzerland
  • Christian Drosten; German Centre for Infection Research, partner site Charite, Berlin, Germany
  • Isabella Anne Eckerle; Department of Microbiology and Molecular Medicine, University of Geneva, Switzerland
  • Ronald Dijkman; Institute for Infectious Diseases, University of Bern, Bern, Switzerland
  • Donata Hoffmann; Institute of Diagnostic Virology, Friedrich Loeffler Institut, Federal Research Institute of Animal Health, Greifswald Insel Riems, Germany
  • Volker Thiel; Institute of Virology and Immunology, Bern, Switzerland
  • Martin Beer; Institute of Diagnostic Virology, Friedrich Loeffler Institut, Federal Research Institute of Animal Health, Greifswald Insel Riems, Germany
  • Charaf Benarafa; Institute of Virology and Immunology, Mittelhaeusern, Switzerland
Preprint en Inglés | bioRxiv | ID: ppbiorxiv-450190
ABSTRACT
Emerging variants of concern (VOCs) drive the SARS-CoV-2 pandemic. We assessed VOC B.1.1.7, now prevalent in several countries, and VOC B.1.351, representing the greatest threat to populations with immunity to the early SARS-CoV-2 progenitors. B.1.1.7 showed a clear fitness advantage over the progenitor variant (wt-S614G) in ferrets and two mouse models, where the substitutions in the spike glycoprotein were major drivers for fitness advantage. In the "superspreader" hamster model, B.1.1.7 and wt-S614G had comparable fitness, whereas B.1.351 was outcompeted. The VOCs had similar replication kinetics as compared to wt-S614G in human airway epithelial cultures. Our study highlights the importance of using multiple models for complete fitness characterization of VOCs and demonstrates adaptation of B.1.1.7 towards increased upper respiratory tract replication and enhanced transmission in vivo. Summary sentenceB.1.1.7 VOC outcompetes progenitor SARS-CoV-2 in upper respiratory tract replication competition in vivo.
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Texto completo: Disponible Colección: Preprints Base de datos: bioRxiv Idioma: Inglés Año: 2021 Tipo del documento: Preprint
Texto completo
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Texto completo: Disponible Colección: Preprints Base de datos: bioRxiv Idioma: Inglés Año: 2021 Tipo del documento: Preprint