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No association between circulating levels of testosterone and sex hormone-binding globulin and risk of COVID-19 mortality in UK biobank
Preprint
en Inglés
| medRxiv
| ID: ppmedrxiv-20191783
ABSTRACT
Background:
Sex-disaggregated data suggest that men with coronavirus disease 2019 (COVID-19) are more likely to die than women. Whether circulating testosterone or sex hormone-binding globulin (SHBG) contributes to such sex differences remains unknown.Objective:
To evaluate the associations of circulating total testosterone (TT), free testosterone (FT), and SHBG with COVID-19 mortality.Design:
Prospective analysis.Setting:
UK Biobank.Participants:
We included 1306 COVID-19 patients (678 men and 628 women) who had serum TT and SHBG measurements and were free of cardiovascular disease or cancer at baseline (2006-2010). Main outcomemeasures:
The death cases of COVID-19 were identified from National Health Service death records updated at 31 July 2020. Unconditional logistic regression was performed to estimate the odds ratio (OR) and 95% confidence intervals (CI) for mortality.Results:
We documented 315 deaths of COVID-19 (194 men and 121 women). After adjusting for potential confounders, we did not find any statistically significant associations for TT (OR per 1-SD increase = 1.03, 95% CI 0.85-1.25), FT (OR per 1-SD increase = 0.95, 95% CI 0.77-1.17), or SHBG (OR per 1-SD increase = 1.09, 95% CI 0.87-1.37) with COVID-19 mortality in men. Similar null results were observed in women (TT OR per 1-SD increase = 1.10, 95% CI 0.85-1.42; FT OR per 1-SD increase = 1.10, 95% CI 0.82-1.46; SHBG OR per 1-SD increase = 1.16, 95% CI 0.89-1.53).Conclusions:
Our findings do not support a significant role of circulating testosterone or SHBG in COVID-19 prognosis.
cc_by_nc_nd
Texto completo:
Disponible
Colección:
Preprints
Base de datos:
medRxiv
Tipo de estudio:
Experimental_studies
/
Estudio observacional
/
Estudio pronóstico
Idioma:
Inglés
Año:
2020
Tipo del documento:
Preprint