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Typically asymptomatic but with robust antibody formation: Childrens unique humoral immune response to SARS-CoV-2
Hanna Renk; Alex Dulovic; Matthias Becker; Dorit Fabricius; Maria Zernickel; Daniel Junker; Alina Seidel; Ruediger Gross; Alexander Hilger; Sebastian Bode; Linus Fritsch; Pauline Frieh; Anneke Haddad; Tessa Goerne; Jonathan Remppis; Tina Ganzenmueller; Andrea Dietz; Daniela Huzly; Hartmut Hengel; Klaus Kaier; Susanne Weber; Eva-Maria Jacobsen; Philipp Kaiser; Bjoern Traenkle; Ulrich Rothbauer; Maximilian Stich; Burkhard Toenshoff; Georg Friedrich Hoffmann; Barbara Mueller; Bernd Jahrsdoerfer; Carolin Ludwig; Hubert Schrezenmeier; Andreas Peter; Sebastian Hoerber; Thomas Iftner; Jan Muench; Thomas Stamminger; Martin Wolkewitz; Corinna Engel; Marta Rizzi; Hans-Juergen Gross; Axel Franz; Philipp Henneke; Klaus-Michael Debatin; Nicole Schneiderhan-Marra; Ales Janda; Roland Elling.
Afiliación
  • Hanna Renk; Department of Haematology and Oncology, University Children's Hospital Tuebingen, Tuebingen, Germany
  • Alex Dulovic; NMI Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen, Germany
  • Matthias Becker; NMI Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen, Germany
  • Dorit Fabricius; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University, Ulm, Germany,
  • Maria Zernickel; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University, Ulm, Germany
  • Daniel Junker; NMI Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen, Germany
  • Alina Seidel; Institute of Molecular Virology, Ulm University, Ulm, Germany
  • Ruediger Gross; Institute of Molecular Virology, Ulm University, Ulm, Germany
  • Alexander Hilger; Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany
  • Sebastian Bode; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University, Ulm, Germany
  • Linus Fritsch; Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany
  • Pauline Frieh; Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany
  • Anneke Haddad; Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany
  • Tessa Goerne; Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany
  • Jonathan Remppis; University Childrens Hospital Tuebingen, Tuebingen, Germany
  • Tina Ganzenmueller; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, Tuebingen, Germany
  • Andrea Dietz; Institute of Virology, Ulm University Medical Center, Ulm, Germany
  • Daniela Huzly; Institute of Virology, Medical Center - University of Freiburg, Faculty of Medicine, University of F
  • Hartmut Hengel; Institute of Virology, University Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany
  • Klaus Kaier; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg
  • Susanne Weber; Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
  • Eva-Maria Jacobsen; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University, Ulm, Germany
  • Philipp Kaiser; NMI Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen, Germany
  • Bjoern Traenkle; NMI Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen, Germany
  • Ulrich Rothbauer; NMI Natural and Medical Sciences Institute at the University of Tuebingen, Reutlingen, Germany
  • Maximilian Stich; Department of Pediatrics I, University Childrens Hospital Heidelberg, Heidelberg, Germany
  • Burkhard Toenshoff; Department of Pediatrics I, University Childrens Hospital Heidelberg, Heidelberg, Germany
  • Georg Friedrich Hoffmann; Department of Pediatrics I, University Childrens Hospital Heidelberg, Heidelberg, Germany
  • Barbara Mueller; Department of Infectious Diseases, Virology, Heidelberg University, Heidelberg, Germany
  • Bernd Jahrsdoerfer; Department of Transfusion Medicine, Ulm University, Ulm, Germany
  • Carolin Ludwig; Department of Transfusion Medicine, Ulm University, Ulm, Germany
  • Hubert Schrezenmeier; Department of Transfusion Medicine, Ulm University, Ulm, Germany
  • Andreas Peter; Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tuebingen, Tuebingen, Germany
  • Sebastian Hoerber; Institute for Clinical Chemistry and Pathobiochemistry, University Hospital Tuebingen, Tuebingen, Germany
  • Thomas Iftner; Institute for Medical Virology and Epidemiology of Viral Diseases, University Hospital Tuebingen, Tuebingen, Germany
  • Jan Muench; Institute of Molecular Virology, Ulm University, Ulm, Germany
  • Thomas Stamminger; Institute of Virology, Ulm University Medical Center, Ulm, Germany
  • Martin Wolkewitz; Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany
  • Corinna Engel; University Childrens Hospital Tuebingen, Tuebingen, Germany
  • Marta Rizzi; Department of Rheumatology and Clinical Immunology, Freiburg University Medical Center, Faculty of Medicine, University of Freiburg, Freiburg, Germany
  • Hans-Juergen Gross; Institute of Clinical Chemistry, Ulm University, Ulm, Germany
  • Axel Franz; Centre for Paediatric Clinical Studies at the University Children's Hospital Tuebingen, Tuebingen, Germany
  • Philipp Henneke; Center for Pediatrics and Adolescent Medicine, Medical Center Freiburg, Germany and Faculty of Medicine, University of Freiburg, Freiburg, Germany
  • Klaus-Michael Debatin; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University, Ulm, Germany
  • Nicole Schneiderhan-Marra; NMI Natural and Medical Sciences Institute at the University of Tuebingen
  • Ales Janda; Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm University, Ulm, Germany
  • Roland Elling; University Medial Center Freiburg, Center of Pediatrics and Adolescent Medicine
Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21260863
ABSTRACT
BackgroundLong-term persistence of antibodies against SARS-CoV-2, particularly the SARS-CoV-2 Spike Trimer, determines individual protection against infection and potentially viral spread. The quality of childrens natural humoral immune response following SARS-CoV-2 infection is yet incompletely understood but crucial to guide pediatric SARS-CoV-2 vaccination programs. MethodsIn this prospective observational multi-center cohort study, we followed 328 households, consisting of 548 children and 717 adults, with at least one member with a previous laboratory-confirmed SARS-CoV-2 infection. The serological response was assessed at 3-4 months and 11-12 months after infection using a bead-based multiplex immunoassay for 23 human coronavirus antigens including SARS-CoV-2 and its Variants of Concern (VOC) and endemic human coronaviruses (HCoVs), and additionally by three commercial SARS-CoV-2 antibody assays. ResultsOverall, 33.76% of SARS-CoV-2 exposed children and 57.88% adults were seropositive. Children were five times more likely to have seroconverted without symptoms compared to adults. Despite the frequently asymptomatic course of infection, children had higher specific antibody levels, and their antibodies persisted longer than in adults (96.22% versus 82.89% still seropositive 11-12 months post infection). Of note, symptomatic and asymptomatic infections induced similar humoral responses in all age groups. In symptomatic children, only dysgeusia was found as diagnostic indicator of COVID-19. SARS-CoV-2 infections occurred independent of HCoV serostatus. Antibody binding responses to VOCs were similar in children and adults, with reduced binding for the Beta variant in both groups. ConclusionsThe long-term humoral immune response to SARS-CoV-2 infection in children is robust and may provide long-term protection even after asymptomatic infection. (Study ID at German Clinical Trials Register 00021521)
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Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Cohort_studies / Experimental_studies / Observational_studies / Prognostic_studies / Rct Idioma: En Año: 2021 Tipo del documento: Preprint
Texto completo
Añadir a Mi BVS
Imprimir
XML
Buscar en Google
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Cohort_studies / Experimental_studies / Observational_studies / Prognostic_studies / Rct Idioma: En Año: 2021 Tipo del documento: Preprint