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Global disparities in SARS-CoV-2 genomic surveillance
Anderson F Brito; Elizaveta Semenova; Gytis Dudas; Gabriel W. W Hassler; Chaney Kalinich; Moritz Kraemer; Joses Ho; Houriiyah Tegally; George Githinji; Charles Agoti; Lucy Matkin; Charles Whittaker; - Danish Covid-19 Genome Consortium; - COVID-19 Impact Project; - Swiss SARS-CoV-2 Sequencing Consortium; - Bulgarian SARS-CoV-2 sequencing group; - Network for Genomic Surveillance in South Africa (NGS-SA); - GISAID core curation team; Benjamin Howden; Vitali Sintchenko; Neta Zuckerman; Orna Mor; Heather Blankenship; Tulio de Oliveira; Raymond Lin; Marilda Siqueira; Paola Resende; Ana Tereza Vasconcelos; Fernando Spilki; Renato Santana Aguiar; Ivailo Alexiev; Ivan Ivanov; Ivva Philipova; Christine Carrington; Nikita S.D. Sahadeo; Celine Gurry; Sebastian Maurer-Stroh; Dhamari Naidoo; Karin von Eije; Mark Perkins; Maria van Kerkhove; Sarah Hill; Ester Sabino; Oliver Pybus; Christopher Dye; Samir Bhatt; Seth Flaxman; Marc Suchard; Nathan Grubaugh; Guy Baele; Nuno R. Faria.
Afiliación
  • Anderson F Brito; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA
  • Elizaveta Semenova; Department of Mathematics, Imperial College London, London, UK
  • Gytis Dudas; Gothenburg Global Biodiversity Centre, Gothenburg, Sweden
  • Gabriel W. W Hassler; Department of Computational Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
  • Chaney Kalinich; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA
  • Moritz Kraemer; Department of Zoology, University of Oxford, Oxford, United Kingdom
  • Joses Ho; GISAID Global Data Science Initiative, Munich, Germany
  • Houriiyah Tegally; KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, Sout
  • George Githinji; KEMRI-Wellcome Trust Research Programme, Kenya
  • Charles Agoti; KEMRI-Wellcome Trust Research Programme, Kenya
  • Lucy Matkin; Department of Zoology, University of Oxford, Oxford, United Kingdom
  • Charles Whittaker; MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom.
  • - Danish Covid-19 Genome Consortium;
  • - COVID-19 Impact Project;
  • - Swiss SARS-CoV-2 Sequencing Consortium;
  • - Bulgarian SARS-CoV-2 sequencing group;
  • - Network for Genomic Surveillance in South Africa (NGS-SA);
  • - GISAID core curation team;
  • Benjamin Howden; Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, The University of Melbourne at The Peter Doherty Institute
  • Vitali Sintchenko; Sydney Institute for Infectious Diseases, The University of Sydney, Sydney, New South Wales, Australia
  • Neta Zuckerman; Central Virology Laboratory, Israel Ministry of Health, Sheba Medical Center, Israel
  • Orna Mor; Central Virology Laboratory, Israel Ministry of Health, Sheba Medical Center, Israel
  • Heather Blankenship; Michigan Department of Health and Human Services, Bureau of Laboratories, Lansing, Michigan, USA
  • Tulio de Oliveira; Centre for Epidemic Response and Innovation (CERI), School of Data Science and Computational Thinking, Stellenbosch University, Stellenbosch, South Africa
  • Raymond Lin; National Centre for Infectious Diseases, Singapore
  • Marilda Siqueira; Laboratory of Respiratory Viruses and Measles, FIOCRUZ, Rio de Janeiro, Brazil
  • Paola Resende; Laboratory of Respiratory Viruses and Measles, FIOCRUZ, Rio de Janeiro, Brazil
  • Ana Tereza Vasconcelos; Laboratorio de Bioinformatica, Laboratorio Nacional de Computacao Cientifica, Petropolis, Brazil.
  • Fernando Spilki; Feevale University, Institute of Health Sciences, Novo Hamburgo, Rio Grande do Sul, Brazil
  • Renato Santana Aguiar; Laboratorio de Biologia Integrativa, Departamento de Genetica, Ecologia e Evolucao, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo
  • Ivailo Alexiev; National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria
  • Ivan Ivanov; National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria
  • Ivva Philipova; National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria
  • Christine Carrington; Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago
  • Nikita S.D. Sahadeo; Department of Preclinical Sciences, Faculty of Medical Sciences, The University of the West Indies, St. Augustine, Trinidad and Tobago
  • Celine Gurry; GISAID Global Data Science Initiative, Munich, Germany
  • Sebastian Maurer-Stroh; National Centre for Infectious Diseases, Singapore
  • Dhamari Naidoo; Health Emergencies Programme, World Health Organization Regional Office for South-East Asia, New Delhi, India
  • Karin von Eije; Department of Medical Microbiology and Infection Prevention, Division of Clinical Virology, University Medical Center Groningen, University of Groningen, Gronin
  • Mark Perkins; Emerging Diseases and Zoonoses Unit, Health Emergencies Programme, World Health Organization, Geneva, Switzerland
  • Maria van Kerkhove; Emerging Diseases and Zoonoses Unit, Health Emergencies Programme, World Health Organization, Geneva, Switzerland
  • Sarah Hill; Royal Veterinary College, Hawkshead, United Kingdom
  • Ester Sabino; Instituto de Medicina Tropical, Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo, Brazil.
  • Oliver Pybus; Department of Zoology, University of Oxford, Oxford, United Kingdom
  • Christopher Dye; Department of Zoology, University of Oxford, Oxford, United Kingdom
  • Samir Bhatt; MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, UK.
  • Seth Flaxman; Department of Computer Science, University of Oxford, Oxford, United Kingdom
  • Marc Suchard; Department of Computational Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, USA
  • Nathan Grubaugh; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA
  • Guy Baele; Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium
  • Nuno R. Faria; Department of Zoology, University of Oxford, Oxford, United Kingdom.
Preprint en Inglés | medRxiv | ID: ppmedrxiv-21262393
ABSTRACT
Genomic sequencing provides critical information to track the evolution and spread of SARS-CoV-2, optimize molecular tests, treatments and vaccines, and guide public health responses. To investigate the spatiotemporal heterogeneity in the global SARS-CoV-2 genomic surveillance, we estimated the impact of sequencing intensity and turnaround times (TAT) on variant detection in 167 countries. Most countries submit genomes >21 days after sample collection, and 77% of low and middle income countries sequenced <0.5% of their cases. We found that sequencing at least 0.5% of the cases, with a TAT <21 days, could be a benchmark for SARS-CoV-2 genomic surveillance efforts. Socioeconomic inequalities substantially impact our ability to quickly detect SARS-CoV-2 variants, and undermine the global pandemic preparedness. One-Sentence SummarySocioeconomic inequalities impacted the SARS-CoV-2 genomic surveillance, and undermined the global pandemic preparedness.
Licencia
cc_by_nc_nd
Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Idioma: Inglés Año: 2021 Tipo del documento: Preprint
Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Idioma: Inglés Año: 2021 Tipo del documento: Preprint
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