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Higher mortality associated with the SARS-CoV-2 Delta variant in the Western Cape, South Africa, using RdRp target delay as a proxy
Hannah Hussey; Mary-Ann Davies; Alexa Heekes; Carolyn Williamson; Ziyaad Valley-Omar; Diana Ruth Hardie; Stephen Korsman; Deelan Doolabh; Wolfgang Preiser; Tongai Maponga; Arash Iranzadeh; Sean Wasserman; Neshaad Schrueder; Linda Boloko; Peter Raubenheimer; Greg Symons; Arifa Parker; Abraham Viljoen; Cheryl Cohen; WAASILA JASSAT; Richard Lessels; Robert J Wilkinson; Andrew Boulle; Nei-yuan Marvin Hsiao.
Afiliación
  • Hannah Hussey; University of Cape Town
  • Mary-Ann Davies; University of Cape Town
  • Alexa Heekes; University of Cape Town
  • Carolyn Williamson; University of Cape Town
  • Ziyaad Valley-Omar; National Health Laboratory Service of South Africa
  • Diana Ruth Hardie; University of Cape Town
  • Stephen Korsman; University of Cape Town
  • Deelan Doolabh; University of Cape Town
  • Wolfgang Preiser; University of Stellenbosch
  • Tongai Maponga; University of Stellenbosch
  • Arash Iranzadeh; University of Cape Town
  • Sean Wasserman; University of Cape Town
  • Neshaad Schrueder; University of Stellenbosch
  • Linda Boloko; University of Cape Town
  • Peter Raubenheimer; University of Cape Town
  • Greg Symons; University of Cape Town
  • Arifa Parker; University of Stellenbosch
  • Abraham Viljoen; University of Stellenbosch
  • Cheryl Cohen; National Insitute for Communicable Diseases
  • WAASILA JASSAT; National Institute for Communicable Diseases
  • Richard Lessels; University of KwaZulu Natal
  • Robert J Wilkinson; University of Cape Town
  • Andrew Boulle; University of Cape Town
  • Nei-yuan Marvin Hsiao; University of Cape Town
Preprint en En | PREPRINT-MEDRXIV | ID: ppmedrxiv-21265412
ABSTRACT
A novel proxy for the Delta variant, RNA-dependent RNA polymerase target delay in the Seegene Allplex 2019-nCoV PCR assay, was associated with higher mortality (adjusted Odds Ratio 1.45 [95%CI 1.13-1.86]), compared to presumptive Beta infection, in the Western Cape, South Africa (April-July 2021). Prior diagnosed infection and vaccination were protective.
Licencia
cc_by_nc_nd
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Prognostic_studies Idioma: En Año: 2021 Tipo del documento: Preprint
Texto completo: 1 Colección: 09-preprints Base de datos: PREPRINT-MEDRXIV Tipo de estudio: Prognostic_studies Idioma: En Año: 2021 Tipo del documento: Preprint