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Comparison of infectious SARS-CoV-2 from the nasopharynx of vaccinated and unvaccinated individuals
Mario A. Pena-Hernandez; Jon Klein; Amyn Malik; Andreas Coppi; Chaney C Kalinich; Chantal B.F. Vogels; Julio Silva; - Yale SARS-CoV-2 Genomic Surveillance Initiative; David R. Peaper; Marie Landry; Craig Wilen; Nathan D Grubaugh; Wade L Schulz; Saad B. Omer; Akiko Iwasaki.
Afiliación
  • Mario A. Pena-Hernandez; Yale University School of Medicine
  • Jon Klein; Yale University School of Medicine
  • Amyn Malik; Yale School of Public Health
  • Andreas Coppi; Yale University School of Medicine
  • Chaney C Kalinich; Yale School of Public health
  • Chantal B.F. Vogels; Yale School of Public Health
  • Julio Silva; Yale University School of Medicine
  • - Yale SARS-CoV-2 Genomic Surveillance Initiative;
  • David R. Peaper; Yale University School of Medicine
  • Marie Landry; Yale University School of Medicine
  • Craig Wilen; Yale University School of Medicine
  • Nathan D Grubaugh; Yale School of Public Health
  • Wade L Schulz; Yale University School of Medicine
  • Saad B. Omer; Yale School of Public Health
  • Akiko Iwasaki; Yale University School of Medicine
Preprint en Inglés | medRxiv | ID: ppmedrxiv-21268460
ABSTRACT
The frequency of SARS-CoV-2 breakthrough infections in fully vaccinated individuals increased with the emergence of the Delta variant, particularly with longer time from vaccine completion. However, whether breakthrough infections lead to onward transmission remains unclear. Here, we conducted a study involving 125 patients comprised of 72 vaccinated and 53 unvaccinated individuals, to assess the levels of infectious virus in vaccinated and unvaccinated individuals. Quantitative plaque assays showed no significant differences in the titers of virus between these cohorts. However, the proportion of nasopharyngeal samples with culturable virus was lower in the vaccinated patients relative to unvaccinated patients (21% vs. 40%). Finally, time-to-event analysis with Kaplan-Myer curves revealed that protection from culturable infectious virus waned significantly starting at 5 months after completing a 2-dose regimen of mRNA vaccines. These results have important implications in timing of booster dose to prevent onward transmission from breakthrough cases.
Licencia
cc_by_nc_nd
Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Tipo de estudio: Cohort_studies / Estudio observacional / Estudio pronóstico Idioma: Inglés Año: 2022 Tipo del documento: Preprint
Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Tipo de estudio: Cohort_studies / Estudio observacional / Estudio pronóstico Idioma: Inglés Año: 2022 Tipo del documento: Preprint
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