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Evolution of long-term hybrid immunity in healthcare workers after different COVID-19 vaccination regimens: a longitudinal observational cohort study
Shona C Moore; Barbara Kronsteiner; Stephanie Longet; Sandra Adele; Alexandra S Deeks; Chang Liu; Wanwisa Dejnirattisai; Laura Silva Reyes; Naomi Meardon; Sian Faustini; Saly Al-Taei; Tom Tipton; Luisa M Hering; Adrienn Angyal; Rebecca Brown; Alexander R Nicols; Susan L Dobson; Piyada Supasa; Aekkachai Tuekprakhon; Andrew Cross; Jessica K Tyerman; Hailey Hornsby; Irina Grouneva; Megan Plowright; Peijun Zhang; Thomas A.H. Newman; Jeremy M. Nell; Priyanka Abraham; Mohammad Ali; Tom Malone; Isabel Neale; Eloise Phillips; Joseph D. Wilson; Martha Zewdie; Adrian Shields; Emily C. Horner; Lucy H. Booth; Lizzie Stafford; Sagida Bibi; Daniel G. Wootton; Alexander J. Mentzer; Christopher P. Conlon; Katie Jeffery; Philippa C. Matthews; Andrew J. Pollard; Anthony Brown; Sarah L. Rowland-Jones; Juthathip Mongkolsapaya; Rebecca P. Payne; Christina Dold; Teresa Lambe; James E.D. Thaventhiran; Gavin Screaton; Eleanor Barnes; Susan Hopkins; Victoria Hall; Christopher JA Duncan; Alex Richter Richter; Miles Carroll; Thushan I. de Silva; Paul Klenerman; Susanna Dunachie; Lance Turtle; - PITCH Consortium.
Afiliación
  • Shona C Moore; University of Liverpool
  • Barbara Kronsteiner; University of Oxford
  • Stephanie Longet; University of Oxford
  • Sandra Adele; University of Oxford
  • Alexandra S Deeks; University of Oxford
  • Chang Liu; University of Oxford
  • Wanwisa Dejnirattisai; University of Oxford
  • Laura Silva Reyes; University of Oxford
  • Naomi Meardon; University of Sheffield
  • Sian Faustini; University of Birmingham
  • Saly Al-Taei; University of Birmingham
  • Tom Tipton; University of Oxford
  • Luisa M Hering; University of Liverpool
  • Adrienn Angyal; University of Sheffield
  • Rebecca Brown; University of Sheffield
  • Alexander R Nicols; Newcastle University
  • Susan L Dobson; University of Liverpool
  • Piyada Supasa; University of Oxford
  • Aekkachai Tuekprakhon; University of Oxford
  • Andrew Cross; University of Liverpool
  • Jessica K Tyerman; Newcastle University
  • Hailey Hornsby; University of Sheffield
  • Irina Grouneva; University of Sheffield
  • Megan Plowright; University of Sheffield
  • Peijun Zhang; University of Sheffield
  • Thomas A.H. Newman; University of Sheffield
  • Jeremy M. Nell; Newcastle University
  • Priyanka Abraham; University of Oxford
  • Mohammad Ali; University of Oxford
  • Tom Malone; University of Oxford
  • Isabel Neale; University of Oxford
  • Eloise Phillips; University of Oxford
  • Joseph D. Wilson; University of Oxford
  • Martha Zewdie; Peter Medawar Building for Pathogen Research, Nuffield Dept. of Clinical Medicine, University of Oxford, UK
  • Adrian Shields; University of Birmingham
  • Emily C. Horner; University of Cambridge
  • Lucy H. Booth; University of Cambridge
  • Lizzie Stafford; University of Oxford
  • Sagida Bibi; University of Oxford
  • Daniel G. Wootton; University of Liverpool
  • Alexander J. Mentzer; University of Oxford
  • Christopher P. Conlon; University of Oxford
  • Katie Jeffery; University of Oxford
  • Philippa C. Matthews; University of Oxford
  • Andrew J. Pollard; University of Oxford
  • Anthony Brown; University of Oxford
  • Sarah L. Rowland-Jones; University of Sheffield
  • Juthathip Mongkolsapaya; University of Oxford
  • Rebecca P. Payne; Newcastle University
  • Christina Dold; University of Oxford
  • Teresa Lambe; University of Oxford
  • James E.D. Thaventhiran; University of Cambridge
  • Gavin Screaton; University of Oxford
  • Eleanor Barnes; University of Oxford
  • Susan Hopkins; UK Health Security Agency
  • Victoria Hall; UK Health Security Agency
  • Christopher JA Duncan; Newcastle University
  • Alex Richter Richter; University of Birmingham
  • Miles Carroll; University of Oxford
  • Thushan I. de Silva; University of Sheffield
  • Paul Klenerman; University of Oxford
  • Susanna Dunachie; University of Oxford
  • Lance Turtle; University of Liverpool
  • - PITCH Consortium;
Preprint en Inglés | medRxiv | ID: ppmedrxiv-22275865
ABSTRACT
Both infection and vaccination, alone or in combination, generate antibody and T cell responses against SARSCoV2. However, the maintenance of such responses, and hence protection from disease, requires careful characterisation. In a large prospective study of UK healthcare workers (Protective immunity from T cells in Healthcare workers (PITCH), within the larger SARSCoV2 immunity and reinfection evaluation (SIREN) study) we previously observed that prior infection impacted strongly on subsequent cellular and humoral immunity induced after long and short dosing intervals of BNT162b2 (Pfizer/BioNTech) vaccination. Here, we report longer follow up of 684 HCWs in this cohort over 6-9 months following two doses of BNT162b2 or AZD1222 (Oxford/AstraZeneca) vaccination and up to 6 months following a subsequent mRNA booster vaccination. We make three observations Firstly, the dynamics of humoral and cellular responses differ; binding and neutralising antibodies declined whereas T and memory B cell responses were maintained after the second vaccine dose. Secondly, vaccine boosting restored IgG levels, broadened neutralising activity against variants of concern including omicron BA.1, BA.2 and BA.5, and boosted T cell responses above the 6 month level post dose 2. Thirdly, prior infection maintained its impact driving larger as well as broader T cell responses compared with never-infected people, a feature maintained until 6 months after the third dose. In conclusion, broadly cross-reactive T cell responses are well maintained over time, especially in those with combined vaccine and infection-induced immunity (hybrid immunity), and may contribute to continued protection against severe disease.
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Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Tipo de estudio: Cohort_studies / Experimental_studies / Estudio observacional / Estudio pronóstico / Rct Idioma: Inglés Año: 2022 Tipo del documento: Preprint
Texto completo: Disponible Colección: Preprints Base de datos: medRxiv Tipo de estudio: Cohort_studies / Experimental_studies / Estudio observacional / Estudio pronóstico / Rct Idioma: Inglés Año: 2022 Tipo del documento: Preprint
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