Research advances on the role of ACSL3 in the atherosclerosis / 生理学报
Acta Physiologica Sinica
; (6): 587-594, 2023.
Article
en Zh
| WPRIM
| ID: wpr-1007774
Biblioteca responsable:
WPRO
ABSTRACT
Lipids droplets are organelles that store neutral lipids and are closely related to lipid accumulation. Long chain acyl-coenzyme A synthetase 3 (ACSL3) is a lipid droplet-associated protein mainly distributed in the cell membrane, endoplasmic reticulum, and intracellular lipid droplets, and its distribution depends on cell type and fatty acid supply. ACSL3 is a key regulator of fatty acid metabolism that is closely related to intracellular lipid accumulation, and plays an important role in various pathophysiological processes such as lipid droplet synthesis and lipid metabolism, cellular inflammation, and ferroptosis. This paper mainly reviews the role of ACSL3 in lipid synthesis, ferroptosis, and inflammatory response, with focus on the mechanism of its role in lipid accumulation in atherosclerosis, and provides new ideas for exploring potential therapeutic targets in atherosclerotic diseases.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Coenzima A Ligasas
/
Retículo Endoplásmico
/
Aterosclerosis
/
Metabolismo de los Lípidos
/
Ácidos Grasos
Límite:
Humans
Idioma:
Zh
Revista:
Acta Physiologica Sinica
Año:
2023
Tipo del documento:
Article